Lrp4 is a multifunctional member of the low density lipoprotein-receptor gene family and a modulator of extracellular cell signaling pathways in development.For example, Lrp4 binds Wise, a secreted Wnt modulator and BMP antagonist.Lrp4 shares structural elements within the extracellular ligand binding domain with Lrp5 and Lrp6, two established Wnt
AimsDue to its high heterogenicity and unclear etiology, there is currently no specific treatment for polycystic ovary syndrome (PCOS).Metformin, as an insulin sensitizer, combined with spironolactone, an antiandrogen medication, may exert complementary effects on PCOS.We therefore performed a meta-analysis of trials in which metformin combined wit
Architected composite metastructures can exhibit a subwavelength ultrawide bandgap (BG) with prominent emerging applications in the structural vibration and noise control and, elastic wave manipulation.The present study implemented both forward and inverse design methods based on numerical Brazil Nuts simulations and machine learning (ML) methods,
Abstract Background Multiple therapies exist for patients with metastatic castration-resistant prostate cancer (mCRPC).However, their improvement on progression-free survival (PFS) remains modest, potentially explained by tumor molecular heterogeneity.Several prognostic molecular biomarkers have been identified for mCRPC that may have predictive po
In recent years, solar photovoltaic power generation has emerged as an essential means of energy supply.The prediction of its active power is not only conducive to cost saving but can also promote the development of solar power generation industry.However, it is challenging to obtain an accurate and high-quality interval prediction of active power.